Request a free sample part Pick a material from the menu below.
formlabs.com |
Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics Biomaterials | Vol 156, Pages 1-274 (February 2018) | ScienceDirect.com by Elsevier
Jinah Jang, Ju Young Park, Ge Gao, Dong-Woo Cho. Pages 88-106 |
WORLD'S FIRST 3D PRINTED EYE Video: 34:13 MIN/SEC INTO VIDEO CTV News London at Six for Friday, November 26, 2021 Source Moorfields Eye Hospital NHS Foundation Trust www.moorfields.nhs.uk/news/moorfields-patient-receives-world-s-first-3d-printed-eye |
3D Printed Shower Cast
Broken bones are inconvenient enough; add a clunky cast and cleaning yourself daily, and it can be downright maddening. The waterproof shower cast makes your healing time breathable, clean and comfortable.
Poly-covered plastic keeps fragile bones and muscles in place comfortably. Showering with a clunky plaster cast is a thing of the past, and you have the added benefit of knowing that you can itch from any angle at any time. |
Biofabrication focuses on cutting-edge research regarding the use of cells, proteins, biological materials and biomaterials as building blocks to manufacture biological systems and/or therapeutic products.
https://iopscience.iop.org/journal/1758-5090 It is also the official journal of the International Society for Biofabrication (ISBF). Image: The term Biofabrication is used to describe natural processes such as biomineralization and technological processes in various disciplines such as catalysis, biotechnology, sensing, synthetic biology, and especially TE and RM. For application within TE and RM, Biofabrication can generally be divided into two distinct approaches, Bioprinting and Bioassembly.
|
Full details of the team’s work on
reappraising this evolving field can be found in the journal Biofabrication The Herston biofabrication center is undoubtedly the first of many similar labs we will be seeing in the future, not only in Australia, but on a national scale. Search Design Indaba
The Design Indaba Emerging Creatives programme presented in collaboration with the Department of Arts and Culture provides support, education and mentoring for South Africa's future designers.
|
Read MTo our knowledge, the term Biofabrication was first coined in 1994 in relation to the biomineralisation of pearls [4] and later, in 2003, also the deposition of enamel in mammalian teeth [5]. In addition, the US Defence Advanced Research Projects Agency used the definition 'Biofabrication--the use of biological materials and mechanisms for construction' to describe methods used to create high-resolution 3D structures that mimic biological growth mechanisms [6]. In 2004, Biofabrication was used by Payne and co-workers to describe the generation of nanostructured assemblies containing biological materials and/or biocatalysts. In their words, they used a rather broad definition: 'the marriage between biology and microfabrication' [7]. Today, the term Biofabrication is broadly used in the context of fabricating organic/inorganic hybrid materials or, more generally, fabrication of materials [8, 9] by living organisms.
The term 'organ printing', on the other hand, first appeared in 2003 and was defined as 'a rapid prototyping computer-aided 3D printing technology, based on using layer-by-layer deposition of cells and/or cell aggregates into a 3D gel with sequential maturation of the printed construct into perfused and vascularized living tissue or organs' [12]. Source: https://iopscience.iop.org/article/10.1088/1758-5090/8/1/013001
.
The term 'organ printing', on the other hand, first appeared in 2003 and was defined as 'a rapid prototyping computer-aided 3D printing technology, based on using layer-by-layer deposition of cells and/or cell aggregates into a 3D gel with sequential maturation of the printed construct into perfused and vascularized living tissue or organs' [12]. Source: https://iopscience.iop.org/article/10.1088/1758-5090/8/1/013001
.
The cutting-edge ways in which biological printers are reshaping medicine.
At the moment we can heal bone, we can heal cartilage, we can make customized ear prosthetics – really, the future is going to be looking at creating tissue constructs and moving towards real organs.
https://3dprintingindustry.com/news/australia-gets-first-institute-biofabrication-human-bones-tissue-99108/ Blood vessels Blood vessels are challenging to grow in the lab, but without them artificial organs would starve for want of nutrients. A team of bioengineers at the University of Pennsylvania has overcome this hurdle with a 3D printer that builds blood vessels from the inside out. The printer lays down an intricate network of sugar filaments to serve as a template for the inside of the vessels. A suspension containing the patient’s liver cells is added, and the cells grow around the sugar to form vessels. The sugar strands are then washed away, leaving behind a living network of blood vessels. |
Skin
Eric Moger lost the left side of his face as a result of cancer several years ago. Chemotherapy eliminated the possibility of plastic surgery, leaving him with a gaping hole in his face. Thanks to 3D printing, he received a lifelike prosthetic face made of toughened nylon plastic earlier this year. Surgeons printed a mirror image of a 3D scan of the right side of his face, which was then attached to a titanium scaffold. For less drastic cases, researchers at the Wake Forest Institute for Regenerative Medicine are working on a 3D printer that can print living cells directly onto burns and other wounds. |
Breast implants
With nearly 50,000 cases of breast cancer diagnosed in the UK every year, there’s high demand for reconstructive surgery. Partial reconstruction following removal of only the tumour is especially difficult, leaving women with few good options. Research at the University of Texas at El Paso promises to fill the gap by printing a shape-fitted custom implant from the patient’s own fat cells. Using a modified HP Deskjet printer, they lay down layer upon layer of cells to create an implant that fits the excision while minimising the risk of rejection or other complications. |
|
|
Prosthetic limbs
Amputees can reap the rewards of 3D printing too: printed prosthetics can be custom-fitted, avoiding the need to trim the bone. They’re also cheaper to make and easier to replace than traditional titanium or carbon-fibre limbs. Projects like Handie and Dextrus (see below), which are developing robotic hands, promise to dramatically cut the costs involved and bring these life-changing devices within reach of people with lower incomes. |
3D printable materials are not only accepted by the body, but they are also bio-degradable, as is common in spine surgery, and seen in the fracture fixing silk proteins from researchers in Seoul. Materials having the ability to eventually be absorbed by the body and overtaken by natural human cells can eradicate the need for subsequent operations to remove the implants and, being 3D printed, are capable of more complex and unique structures.
|
Bone
There are obvious advantages to 3D-printed bones – not only can they be custom-fitted to the break, but the technology is ideally suited to mimic the internal structures that make natural bones light and resilient. In June 2011, an 83-year-old woman in the Netherlands got a 3D-printed prosthetic lower jaw. Made of titanium powder fused together by a laser, it had working joints as well as cavities and grooves for muscles and nerves to reattach. Just this year, US company OsteoFab went even further when they used 3D printing to replace most of a patient’s skull. Car crashes and other serious accidents can call for this sort of major reconstructive surgery, and 3D printing offers the necessary precision and speed at a much lower cost than traditional methods, making these operations cheaper and safer. Current Research outcomes: https://cordis.europa.eu/project/rcn/197262/results/en |
The Herston Health Precinct in Brisbane, Queensland, is in the center of seven of the city’s medical institutes, including the Royal Brisbane and Women’s Hospital (RBWH) that already implements 3D printing as surgical guides. 2017’s redevelopment of the Herston Quarter is going to see the addition of a new specialized biofabrication unit that will model and print materials to be surgically implanted in patients – such as screws, plates and chips for bone-grafts, and eventually tissue and organs made from the patient’s own cells. Read More: 3dprintingindustry.com/news/australia-gets-first-institute-biofabrication-human-bones-tissue-99108/
Biomaterials. 2016 Mar;83:363-82. doi: 10.1016/j.biomaterials.2016.01.024. Epub 2016 Jan 9.Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration.Tang D1, Tare RS2, Yang LY3, Williams DF4, Ou KL5, Oreffo RO6.
Organs
Anthony Atala, the director of the Wake Forest Institute for Regenerative Medicine, is on a mission to make functional human organs with a 3D printer. The printer first builds a scaffold structure upon which it deposits layers of cells that combine to form an organ. Atala has already successfully printed and implanted a bladder, and now he’s set his sights on more complex organs like the kidney and liver. His team has printed a kidney out of human cells, but getting it to work is the trick – for one thing, it needs proper blood vessels to function. While they work on that, the same technology has been used to print clusters of organ cells, like liver cells, which can be used in place of animal testing. |
|
Ears
Replacements for missing or underdeveloped ears are currently built using artificial materials or from transplanted rib tissue, but the results often look unusual and don’t perform very well. A team of doctors at Cornell University plans to remedy this with lifelike bioengineered ears. A 3D printer is used to print a mould that then serves as a template to shape the growth of collagen and cartilage. It takes only a few days for the ears to grow, and they can stay alive and healthy in the lab for several months. If the safety and efficacy tests go well, we may hear about the first human implant in just a few years. |
BONE
|
|
In our research group, we used chemical and biological approaches to create precisely defined nanomaterials, to investigate complex phenomena at their interfaces, and to develop novel, biomimetic, functional materials. Specifically, we focused on bone and its basic building blocks to study the fundamental mechanisms of bone mineralization and resorption and to develop bioinspired functional materials (Fig. 1)
|
Researchers at MIT, Draper, and Brigham and Women’s Hospital have designed an ingestible capsule that can be controlled using Bluetooth wireless technology. The capsule, which can be customized to deliver drugs, sense environmental conditions, or both, can reside in the stomach for at least a month, transmitting information and responding to instructions from a user’s smartphone. http://news.mit.edu/2018/ingestible-pill-controlled-wirelessly-bluetooth-1213
|
|
It Will Be Done By 2030
Children of today are going to be the adults when they want to bring this AI connection in full-blown. For that to happen they have to get people addicted to technology to the point where they'll accept it and where it's the most natural thing in the world and it's happening in front of our eyes the first stage is to get people addicted to technology ... https://www.youtube.com/watch?v=rver8vjc04U |
|
Physics of the Future: How Science Will Shape Human Destiny and Our Daily Lives by the Year 2100 is a 2011 book by theoretical physicist Michio Kaku, author of Hyperspace and Physics of the Impossible. In it Kaku speculates about possible future technological development over the next 100 years |
|
Dr Peter Choong from St Vincent’s Hospital discusses his research with University of Melbourne about extracting cells from a patient to create a gel that will rebuild cartilage in damaged joints, using a ‘Biopen’.
The study demonstrated the capacity of the BioPen to produce human hyaline-like cartilage by coaxial extrusion of hADSC-laden in GelMa/HAMa hydrogel. A handheld device for surgical extrusion can also overcome clinical graft-site mismatch limitations. The previously established core/shell distribution of the scaffold geometry protected the survival and proliferative potential of the hADSCs. Genes expressed during hyaline-like cartilage formation were quantified with qRT-PCR, the expression of SOX9 - the master regulator of chondrogenesis reflected the chondrogenic potential of the stem cells source. Cells similarly expressed COL2A1 (type II collagen found in cartilage) and ACAN (that forms proteoglycan protein) to demonstrate differentiation. |
Bioscaffolds were further tested using non-linear two- photon microscopy and second-harmonic generation (SHG) to detect mature fibrillary collagen after eight weeks of chondrogenesis.
The possibility of delivering osteogenic and chondrogenic growth factors within the hydrogel will be considered in the future. Additional studies will also aim to achieve biomechanical properties for the chondrogenic bioscaffolds comparable to native articular cartilage. Studies hereon will evaluate de novo cartilage formation to understand the interplay between stem cells and 3-D architectured hydrogels with different mechanical and biodegradation properties. 1, 2, 3
The possibility of delivering osteogenic and chondrogenic growth factors within the hydrogel will be considered in the future. Additional studies will also aim to achieve biomechanical properties for the chondrogenic bioscaffolds comparable to native articular cartilage. Studies hereon will evaluate de novo cartilage formation to understand the interplay between stem cells and 3-D architectured hydrogels with different mechanical and biodegradation properties. 1, 2, 3
Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine.
The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Read Contents |
VID-1592880204838 GIF
by Taykaybo | Gfycat
https://gfycat.com/ko/leadingsmugamazonparrot
Watch and share VID-1592880204838 GIFs by Taykaybo on Gfycat.
by Taykaybo | Gfycat
https://gfycat.com/ko/leadingsmugamazonparrot
Watch and share VID-1592880204838 GIFs by Taykaybo on Gfycat.
Cubicreator Softwear
|
Cubicreator Tutorial - Setting up a Print
take a look at what your print is going to look like before you actually print it. |