Michelangelo Buonarroti
Italy 1475 - 1564 Rome (d.89) Michelangelo was an Italian sculptor, painter, architect, and the most famous Florentine artist of the Renaissance.
Michelangelo studied anatomy until he was able to show the human body in every imaginable position. His large, muscular statues have an incredible firmness, strength and reality. Behind much of his work lay symbolic or religious meaning. In the above illustrated painting, Creation of Man. Sistine Chapel, Rome. 1508-1512. Fresco, viewers see God's power in his extended arm and man's helplessness in the languor of Adam who, in the next electric second, will be infused with life by God's touch. The touch is the center and the focus of the picture. To the left of the painting, God's encircling arm brings the two angels into the scene bringing attention to his weary left hand as it touches the angel's shoulder. The Sistine Chapel consumed Michelangelo's health and time as it took four and a half years to complete. The long hours of lying on his back in a faulty posture caused muscle imbalance due to uneven muscle tension and resulted in a curvature of his spine (postural scoliosis) but it was his hands that gave him cause for concern. According to letters written by Michelangelo, he wrote that writing gave him great discomfort. |
By 1552, He suffered from a number of ailments, including joint disease affecting his hands and feet. At the time it was called gout, but that term was used generally for what we would now consider several different types of arthritis. He also had kidney stones, a condition that can accompany gout. Despite this he continued to create one masterpiece after another. At the age of 89, the Rondanini Pieta was Michelangelo's last sculpture which he continued to work on three days before his death. Michelangelo Matter & Spirit The hands of Michelangelo Buonarroti
RANK Ligand Pathway
The critical SIGNALING Pathway that causes osteoclasts and osteoblasts to work together to maintain a balance between resorption and bone formation.
The critical SIGNALING Pathway that causes osteoclasts and osteoblasts to work together to maintain a balance between resorption and bone formation.
RANK: Receptor on Osteoclasts
Ligand: A cytokine stimulated by TNF secreted by Osteoblasts when stimulated by bone resorption RANK Ligand: An essential mediator of osteoclast formation, production and growth and survival in cortical and trabecular bone throughout the skeleton. Immature osteoclasts mature when RANK Ligand binds to RANK. OPG Osteoprotegerin: Neutralizes effects of RANK Ligand and defends against bone loss and destruction What is the role of RANK Ligand and OPG in condition characterized by bone loss and destruction:
Regulation of Osteoclast Activity www.youtube.com/watch?v=GpMV197xZXc Bone Biology
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MEDICATIONS and Osteoporosis
Drug-induced osteoporosis is common and has a significant impact on the prognosis of patients suffering from chronic debilitating diseases. Glucocorticoids are the drugs causing osteoporotic fractures most frequently, but osteoporosis with fractures is observed also in women treated with aromatase inhibitors for breast cancer, in men receiving anti-androgen therapy for prostate cancer, in postmenopausal women treated with high doses of thyroxine, and in men and women treated with thiazolinediones for type 2 diabetes mellitus. Bone loss with fractures also occurs in patients treated with drugs targeting the immune system, such as calcineurin inhibitors, antiretroviral drugs, selective inhibitors of serotonin reuptake, anticonvulsants, loop diuretics, heparin, oral anticoagulants, and proton pump inhibitors. (1)
Antiseizure Medications
When educating a patient about the use of antiseizure medication, medical professionals should inform the patient/care taker of the long-term use of the medication in women which is Osteoporosis; because of bone loss associated with the long-term use of antiseizure medications, patients receiving antiseizure agents should be assessed for low bone mass and osteoporosis. They should be instructed about strategies to reduce their risks of osteoporosis. (1), (2), (3)
Drug-induced osteoporosis is common and has a significant impact on the prognosis of patients suffering from chronic debilitating diseases. Glucocorticoids are the drugs causing osteoporotic fractures most frequently, but osteoporosis with fractures is observed also in women treated with aromatase inhibitors for breast cancer, in men receiving anti-androgen therapy for prostate cancer, in postmenopausal women treated with high doses of thyroxine, and in men and women treated with thiazolinediones for type 2 diabetes mellitus. Bone loss with fractures also occurs in patients treated with drugs targeting the immune system, such as calcineurin inhibitors, antiretroviral drugs, selective inhibitors of serotonin reuptake, anticonvulsants, loop diuretics, heparin, oral anticoagulants, and proton pump inhibitors. (1)
Antiseizure Medications
When educating a patient about the use of antiseizure medication, medical professionals should inform the patient/care taker of the long-term use of the medication in women which is Osteoporosis; because of bone loss associated with the long-term use of antiseizure medications, patients receiving antiseizure agents should be assessed for low bone mass and osteoporosis. They should be instructed about strategies to reduce their risks of osteoporosis. (1), (2), (3)
Scientific instrument to measure bones
Bone density
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*Nurse gets RELIEF* Herniated Disc, Neck, Knee and TMJ!
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The main way to determine your bone density is to have a dual-energy x-ray absorptiometry (DXA) that measures the mineral content of bone. The measurements, known as T-scores, determine which category a person falls into:
• If your T-score is –1 or greater: your bone density is considered normal. • If your T-score is between –1 and –2.5: you have low bone density, known as Osteopenia • If your T-score is –2.5 or less: you have Osteoporosis, even if you haven't yet broken a bone. Fracture risk increases as bone mineral density declines. A study published in the Journal of the American Medical Association in 2001 reported that a 50-year-old white woman with a T-score of -1 has a 16% chance of fracturing a hip, a 27% chance with a -2 score, and a 33% chance with a -2.5 score. Osteopenia Prevention Everybody's bones get weaker as they get older. But certain choices and habits accelerate the process. They include:
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Dr Rahim Chiropractic
*Nurse gets RELIEF* Herniated Disc, Neck, Knee and TMJ! Dr Rahim Chiropractic: [email protected] http://drrahim.com http://instagram.com/drrahimdc http://facebook.com/drrahimdc About the Gonstead Technique at Centre Chiropractic, State College / Boalsburg PA Video: https://www.youtube.com/watch?v=EMsRAerkNr4 |
TWITCH under the LEFT EYE or that Leg cramp
https://www.youtube.com/watch?v=XeHl5Y7m1xM&list=PLUMm8eUg1aDS6TeX4GSDUnOY9X_ua64a0&index=50&t=0s |
Serious Excess Calcium Side Effects (Soft-Tissue Calcium) - Dr. Berg
https://www.youtube.com/watch?v=J-oDjYNmKgo&list=PLUMm8eUg1aDS6TeX4GSDUnOY9X_ua64a0&index=41 |
A lot of the advice that you're given by your doctor particularly if you have medical care and you're over 65 is incorrect..
Lessons From A 95-Year-Old Bodybuilder
Dustin Lapray https://www.bodybuilding.com/fun/lessons-from-a-95-year-old-bodybuilder.html Osteoporosis / From Sickness to Health - Barbara O'Neill
Osteoarthritis
is derived from the Greek word part osteo-, meaning "of the bone", combined with arthritis: arthr-, meaning "joint", and -itis, the meaning of which has come to be associated with inflammation.[142] The -itis of osteoarthritis could be considered misleading as inflammation is not a conspicuous feature. Some clinicians refer to this condition as osteoarthrosis to signify the lack of inflammatory response.[143] |
Hypercalcemia
is a condition in which the calcium level in your blood is above normal. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work. Hypercalcemia is usually a result of overactive parathyroid glands.
Three causes of hypercalcemia:
1. Immobilization How does immobilization cause hypercalcemia? You have to bear weight to keep Ca in the bone 2. Thiazides retain calcium (Ca) The main thiazides are: hydrochlorothiazide - medication is used to treat high blood pressure chlorthalidone - treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, kidney disorders, or edema caused by taking steroids or estrogen. Chlorthalidone is also used to treat high blood pressure (hypertension). metolazone - is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Metolazone is used to treat fluid retention (edema) in people with congestive heart failure, or a kidney disorder such as nephrotic syndrome. What are the adverse effects of thiazides? Hypokalemia, Hyponatremia, Hyperuricemia, Volume depletion, Hyperglycemia, Hyperlipidemia, Hypersensitivity, Sexual dysfunction 3. Hyperparathyroidism: cause = Excess Parathyroid Hormone What triggers the release of parathyroidhormone? When serum calcium levels decrease Excess Parathyroid Hormone pulls Ca from the bones and puts it in the blood this serum Ca increases Management of Hypercalcemia
The Dangerous State of Too Much CALCIUM! Watch Video: https://www.youtube.com/watch?v=wFjuHpnCrZA&pbjreload=10 Clinical manifestations of hypercalcemia * Bones - painful bones, fractures (due to increased bone remodeling). * Most pts are asymptomatic; maybe arrhythmias. * Increases excitation threshold for heart, nerves, & muscle --> stronger stimulus needed for activation/contraction. * Stones - kidney stones (hypercalciuria --> calcium oxalate & phosphate stones), nephrogenic DI - polyuria, nocturia. * Abdominal groans - ileus, constipation (decreased contraction of the muscles of the GI tract), N/V. * Psychic moans - weakness, fatigue, AMS, decreased DTRs, depression or psychosis may develop; blurred vision. Lab findings w/ hypercalcemia Elevated ionized Ca2+ (most accurate), elevated total serum Ca2+ (> 10mg/dl). PTH-related protein; 1,25-vitamin D levels; 24h urinary calcium. EKG findings w/ hypercalcemia Shortened QT interval, prolonged PR interval, QRS widening. |
Hypercalcemia rarely occurs because of diet alone. It is possible for people with kidney issues, hyperparathyroidism, malignant tumors, lithium use, Hypervitaminosis A , or if you are suffering from Hypervitaminosis D to suffer from hypercalcemia from dietary sources. Most people develop hypercalcemia from taking in too much calcium from supplements and dietary choices. You also have to be careful when using the antacid calcium carbonate in large dose s (doses outside recommended therapeutic range on the drug notes, also known as milk - alkali syndrome) which can easily cause hypercalcemia.
Symptoms of mild /moderate hypercalcemia include loss of appetite, nausea, vomiting, constipation, abdominal cramps, dry mouth, thirst, bone pain, depression, kidney stones, and frequent urination. Abnormal heart rhythm and calcification of arteries can also occur. Mild to moderate symptoms of hypercalcemia are common if your total calcium blood level is around 12 mg/dl.
Symptoms of severe hypercalcemia, on the other hand, is very serious and include confusion, delirium, and coma . Severe symptoms of hypercalcemia are
common if your total calcium blood level is above 15 mg/dl. Hypercalcemia is usually treated by increased hydration to eliminate calcium; diuretic may also be needed for greater kidney clearance of calcium. Bisphosphonates and calcitonin may also be given to prevent bone reabsorption of calcium.
Calcium is not need ed to be supplemented by most people because enough is usually obtained through the diet. Some women with osteoporosis may choose to supplement with calcium to increase bone strength. Remember to supplement with magnesium if you choose to take a calcium supplement. Supplementation of magnesium helps the body eliminate excess calcium, and maintain mineral homeostasis. Remember if you do supplement with calcium, supplement with the superior citrate form and no more than 500 mg every twelve hours for maximum absorption.
Symptoms of mild /moderate hypercalcemia include loss of appetite, nausea, vomiting, constipation, abdominal cramps, dry mouth, thirst, bone pain, depression, kidney stones, and frequent urination. Abnormal heart rhythm and calcification of arteries can also occur. Mild to moderate symptoms of hypercalcemia are common if your total calcium blood level is around 12 mg/dl.
Symptoms of severe hypercalcemia, on the other hand, is very serious and include confusion, delirium, and coma . Severe symptoms of hypercalcemia are
common if your total calcium blood level is above 15 mg/dl. Hypercalcemia is usually treated by increased hydration to eliminate calcium; diuretic may also be needed for greater kidney clearance of calcium. Bisphosphonates and calcitonin may also be given to prevent bone reabsorption of calcium.
Calcium is not need ed to be supplemented by most people because enough is usually obtained through the diet. Some women with osteoporosis may choose to supplement with calcium to increase bone strength. Remember to supplement with magnesium if you choose to take a calcium supplement. Supplementation of magnesium helps the body eliminate excess calcium, and maintain mineral homeostasis. Remember if you do supplement with calcium, supplement with the superior citrate form and no more than 500 mg every twelve hours for maximum absorption.
Alkaline phosphatase had the effect of nurturing the growth of these very delicate parts of the intestinal tract that have to do with absorption intestinal alkaline phosphatase. Blood group O has an enzyme three and a half to four times greater that splits cholesterol, it increases the absorption of calcium (Bone formation through enzymatic hydrolysis of orthophosphate), and has a slight healing effect in the digestive tract in and of itself. (1)
Vitamin DRole of Vitamin D in Atherosclerosis The average serum level of 25OHD in RA patients is generally low, which is related to the activity of the disease, and may be used as a reference index for disease activity in RA patients. The correlation analysis between serum 25OHD level and disease activity of rheumatoid arthritis 黄明德杨明峰吴华军 浙江省嘉兴市第一医院检验科浙江省嘉兴市第一医院风湿科 http://new.oversea.cnki.net/KCMS/detail/43.1225.R.20191129.1120.011.html |
Reduced bone mineral content and normal serum osteocalcin in non-steroid-treated patients with juvenile rheumatoid arthritis
Cesare Polito, et al., (Ann Rheum Dis 1995; 54: 193-196) Children with juvenile rheumatoid arthritis (JRA) are at risk for osteoporosis which may result in vertebral compression and fractures of long bones.' Both corticosteroids in JRA (2) and immobilization in adult rheumatoid arthritis (3) have been recognized as causes of osteoporosis. Poor nutrition and decreased appetite, in addition to inadequate sun exposure from decreased outdoor activities, might also affect calcium intake and vitamin D metabolism and therefore bone mineral content (BMC). A reduction in BMC has been reported in a number of JRA patients.(4)(8) However, most of the subjects considered were receiving steroid therapy and from the data reported it is not possible to distinguish the effects of steroids from those caused by the disease itself. The report by Lovell et al.,(14) is the only one to suggest that JRA may per se be associated with bone demineralization. In that study, seven of 15 patients had BMC 2 SD scores below normal and none of the seven was receiving steroid therapy. Unfortunately, no data are available regarding steroid herapy before the study which could have affected bone mass accretion. In the present paper we report the bone mineral status of patients with JRA who never received steroids. The study was designed in an attempt to isolate the effects of the disease itself on bone from those possibly caused by steroid therapy. Conclusion JRA subjects have significantly reduced BMC even in the absence of any steroid therapy. Bone demineralization appears to depend more on disease activity and on reduced motility than on reduced nutrient intake. Note: hypercalciuria is a common finding in JRA subjects |
How to Cleanse Heavy Metals from the Body
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Arthritis vs Arthrosis
Arthritis is an umbrella term. It’s used to describe several conditions that cause inflammation in your joints. In some cases, the inflammation can also affect your skin, muscles, and organs. Examples include osteoarthritis (OA), rheumatoid arthritis (RA), and gout.
Arthrosis is another name for OA, one type of arthritis. It’s the most common type of arthritis, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. It is believed that arthrosis can be caused by vicious developed of lower limbs, flat-foot, hip dislocation, fractures, severe physical exertion, and by normal wear and tear on your joints and cartilage. Cartilage is the slippery tissue that covers the ends of your bones and helps your joints move. Over time, your cartilage can deteriorate and may even disappear completely. This results in bone-to-bone contact in your joints, causing pain, stiffness, and sometimes swelling. Arthrosis can affect any joint in your body. It’s most likely to affect the joints of your hands, neck, knees, and hips. In a clinical study (Gruenwald et al.,2009) |
In the image above, we have a case of arthrosis, where the synovial fluid and partly also the cartilage is gone and has been worn down. This is very painful.
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A total of 177 patients with moderate-to-severe hip or knee osteoarthritis (OA) were tested over a period of 26 weeks in a two-center, two-armed, randomized, double-blind, comparison study.
Here’s what they did:
Group 1 was given a daily dose of 1500 mg of glucosamine,
Group 2 was given 1500 mg glucosamine PLUS 444 mg fish oil. Fish oil is omega-3-oil, which is anti-inflammatory.
The results were:
Group 1 there was an improvement in pain of 41 - 55%, and the mobility was plus/minus, a little better, but not really good.
Group 2 the improvement in pain was almost identical, but the mobility had become significantly better.
It is important to realize we can't just use glyconutrients on their own, if we combine them we can achieve much better results.
The body uses these substances, to put them to work intelligently. The glyconutrients on their own do nothing, they are just there and are processed by the cells. If health care professionals do not prescribe them, patients have no chance; the body can't create them on its own, because something is missing. Therefore, it is important that we add these substances. If we combine them we can achieve much better results.
For example, there are medical preparations on the market, which contain both this glucosamine and also chondroitin sulphate. Both are glyconutrients. You can combine them with hyaluronic acid, which also contains glyconutrients, and you can combine it with sulphur, that is MSM, as an example. And that is a combination, which has been very, very successful and is capable of providing even better results because the problem is approached from different sides. But the glyconutrients are the key, without them, nothing can happen. And without glyconutrients, all these products are significantly less effective.
Source:
1. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Gruenwald J, et al., Adv Ther. 2009 Sep;26(9):858-71.
https://www.ncbi.nlm.nih.gov/pubmed/19756416
2. Treatment: chondroitin and glucosamine are prescribed and physiological procedures to stop the destruction of the cartilage. https://www.getholistichealth.com/…/arthrosis-seven-mistak…/
3. These two mechanisms are able to slow the progression of cartilage destruction and may help to regenerate the joint structure, leading to reduced pain and increased mobility of the affected joint.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150191/
4. Frontiers in Arthritis: Management of Osteoarthritis - A Holistic View By Ashish Anand
5. Contribution of copper and manganese supplementation on the anti-inflammatory effect of nutrient combinations with glucosamine and chondroitin sulphate. B. Fiebich, J. Grünwald. Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2007-981557
Here’s what they did:
Group 1 was given a daily dose of 1500 mg of glucosamine,
Group 2 was given 1500 mg glucosamine PLUS 444 mg fish oil. Fish oil is omega-3-oil, which is anti-inflammatory.
The results were:
Group 1 there was an improvement in pain of 41 - 55%, and the mobility was plus/minus, a little better, but not really good.
Group 2 the improvement in pain was almost identical, but the mobility had become significantly better.
It is important to realize we can't just use glyconutrients on their own, if we combine them we can achieve much better results.
The body uses these substances, to put them to work intelligently. The glyconutrients on their own do nothing, they are just there and are processed by the cells. If health care professionals do not prescribe them, patients have no chance; the body can't create them on its own, because something is missing. Therefore, it is important that we add these substances. If we combine them we can achieve much better results.
For example, there are medical preparations on the market, which contain both this glucosamine and also chondroitin sulphate. Both are glyconutrients. You can combine them with hyaluronic acid, which also contains glyconutrients, and you can combine it with sulphur, that is MSM, as an example. And that is a combination, which has been very, very successful and is capable of providing even better results because the problem is approached from different sides. But the glyconutrients are the key, without them, nothing can happen. And without glyconutrients, all these products are significantly less effective.
Source:
1. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Gruenwald J, et al., Adv Ther. 2009 Sep;26(9):858-71.
https://www.ncbi.nlm.nih.gov/pubmed/19756416
2. Treatment: chondroitin and glucosamine are prescribed and physiological procedures to stop the destruction of the cartilage. https://www.getholistichealth.com/…/arthrosis-seven-mistak…/
3. These two mechanisms are able to slow the progression of cartilage destruction and may help to regenerate the joint structure, leading to reduced pain and increased mobility of the affected joint.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150191/
4. Frontiers in Arthritis: Management of Osteoarthritis - A Holistic View By Ashish Anand
5. Contribution of copper and manganese supplementation on the anti-inflammatory effect of nutrient combinations with glucosamine and chondroitin sulphate. B. Fiebich, J. Grünwald. Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-2007-981557
Healthy Bones
Innerbody’s Innovative Anatomy Explorer Tools -- Featuring Over 1,000 Interactive Body Maps Explore the human body. Innerbody has comprehensive guides that explain your Skeletal System, Muscular System, Cardiovascular System, Digestive System, and more. Innerbody is the largest medical and wellness testing guide online. Click on body part to see more |
The Radium Girls: The Dark Story of America’s Shining Women, Kate Moore tells the story of how these dial painters took on the radium companies that made them sick—as they were dying of radium poisoning.
Video: https://www.youtube.com/watch?v=BlgC4hQ8i5E
Video: https://www.youtube.com/watch?v=BlgC4hQ8i5E
Radium
Radium is a chemical element with the symbol Ra and atomic number 88. It is the sixth element in group 2 of the periodic table, also known as the alkaline earth metals. Pure radium is silvery-white, but it readily reacts with nitrogen on exposure to air, forming a black surface layer of radium nitride.Wikipedia |
Radon
Radon is a chemical element with the symbol Rn and atomic number 86. It is a radioactive, colorless, odorless, tasteless noble gas. It occurs naturally in minute quantities as an intermediate step in the normal radioactive decay chains through which thorium and uranium slowly decay into lead and various other short-lived radioactive elements; radon itself is the immediate decay product of radium.Wikipedia |
Radium
Radium is a chemical element with the symbol Ra and atomic number 88. It is the sixth element in group 2 of the periodic table, also known as the alkaline earth metals. Pure radium is silvery-white, but it readily reacts with nitrogen on exposure to air, forming a black surface layer of radium nitride.Wikipedia |
Radon | US EPA
https://www.epa.gov/radon Exposure to radon is the second leading cause of lung cancer after smoking. Radon is a colorless, odorless, tasteless and invisible gas produced by the decay of naturally occurring uranium in soil and water. |
Medical evidence and patients' testimonials regarding effectiveness of radon spa treatments of various ailments, most notably rheumatoid arthritis are accumulating worldwide. They challenge the premise of the Linear-No-Threshold (LNT) theory that the dose-effect response is the same per unit dose regardless of the total dose. Historically, such inference overshadowed scientific inquiries into the low-dose region and lead to a popular belief that no amount of radiation can be good. Fortunately, the LNT theory, which lacks any scientific basis, did not remain unchallenged. As the reviewed literature suggests, a paradigm shift, reflected in the consideration of hormetic effects at low-doses, is gaining momentum in the scientific community worldwide.
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Doxycycline
Doxycycline is an antibiotic used in the treatment of infections caused by bacteria and certain parasites. It is used to treat bacterial pneumonia, acne, chlamydia infections, early Lyme disease, cholera, typhus, and syphilis. It is also used to prevent malaria and in combination with quinine, to treat malaria Uses This medication is used to treat a wide variety of bacterial infections, including those that cause acne. This medication is also used to prevent malaria. This medication is known as a tetracycline antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections. |
https://regenexx.com/blog/a-case-study-of-severe-ccj-instability-and-our-picl-procedure/
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Every joint in our body has synovial fluid in it. This is the oil in our body that provides nutrition to the cartilage. Two things are required to produce that fluid: movement and compression. So if a joint doesn’t go through its full range—if the hips and knees never go past 90 degrees—the body says ‘I’m not being used’ and starts to degenerate and stops the production of synovial fluid.”
A healthy musculoskeletal system has implications for our wider health. A 2014 study in the European Journal of Preventive Cardiology found that test subjects who showed difficulty getting up off the floor without support of hands, or an elbow, or leg (what’s called the “sitting-rising test”) resulted in a three-year-shorter life expectancy than subjects who got up with ease. Ability to sit and rise from the floor as a predictor of all-cause mortality Leonardo Barbosa Barreto de Brito, et al. Eur J Prev Cardiol, 2014 Jul;21(7):892-8. https://pubmed.ncbi.nlm.nih.gov/23242910/ |
Frequency of
#28 * Tomatidine is a steroidal alkaloid found in skins and leaves of tomatoes. https://archive.org/details/Resonant_Therapy-Molecular_Biology_19 It has been shown to suppress NF-kappaB signaling in LPS-stimulated macrophages, blocking induced expression of iNOS and COX-2. It is a reported functional inhibitor of acid sphingomyelinase. Tomatidine also has antibacterial properties, blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis more potently than normal strains. It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. By reducing ATF4 activity, tomatidine allow skeletal muscle to recover from effects of aging. |