Pathogenic PrimingOn social media, there are many posts claiming that something called "pathogenic priming" is occurring in those who take the COVID-19 vaccine. According to these posts, this is when the vaccine "facilitates" greater infection, rather than preventing it. The Verify team spoke with medical experts to get a better understanding of whether this concept is real, and whether there's been any documented proof of it occurring with the COVID-19 vaccine. VERIFY: What is Pathogenic Priming? Is it causing greater infection from vaccine as claimed online? - YouTube.
The official name is Antibody-dependent enhancement disease. But with RSV this was all caught in early trials and our experts emphasize that these days of vaccine just wouldn't be approved if pathogenic priming existed. So we can verify that these posts on social media are false our experts say, that there's no risk of Pathogenic Priming. The COVID vaccines are safe and effective, said 'Verify', Evan Kozloff. Doctor William Schaffner from Vanderbilt University
"in science, we don't call it pathogenic priming, but there is a kernel of truth to this concept. Under certain very rare circumstances, a body can produce antibodies that when it later encounters the real germ, actually causes enhanced disease. This has been looked for in the laboratory, in animal models, in the early trials Not a single case has a occurred with vaccinated 150 million people in the United States, hasn't happened. You could rest easy" Doctor Sarah Fortune from The Harvard School of Public Health The classic example of that was a vaccine developed against Respiratory syncytial virus (RSV) in the 1960s, when children who got it got sick after they got exposed to RSV. We're looking for this right out of the gate. It went through all of that development but now we know from people they are exceptionally safe. |
Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity ...https://pubmed.ncbi.nlm.nih.gov › 32292901 Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity J Transl Autoimmun. 2020 Apr 9;3:100051. doi: 10.1016/j.jtauto.2020.100051. Conflict of interest statement Dr. Lyons-Weiler has, in the past, served as expert witness in the National Vaccine Injury Compensation Program. Vaccine-associated hypersensitivity What is pathogenic priming? MORE ON pathogenic priming |
Vaccine-associated enhanced disease: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Flor M. Munoz. et al., Vaccine. 2021 May 21; 39(22): 3053–3066.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901381/
Keywords: Adverse event, Immunization, Guidelines, Case definition, Vaccine, Enhanced disease, Respiratory, Systemic disease
This is a Brighton Collaboration case definition of the term "Vaccine-associated Enhanced Disease" (VAED) to be utilized in the evaluation of adverse events following immunization. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) as part of the Safety Platform for Emergency vACcines (SPEAC)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901381/
Keywords: Adverse event, Immunization, Guidelines, Case definition, Vaccine, Enhanced disease, Respiratory, Systemic disease
This is a Brighton Collaboration case definition of the term "Vaccine-associated Enhanced Disease" (VAED) to be utilized in the evaluation of adverse events following immunization. The case definition was developed by a group of experts convened by the Coalition for Epidemic Preparedness Innovations (CEPI) as part of the Safety Platform for Emergency vACcines (SPEAC)
- Vaccine-associated enhanced diseases (VAED)
- Vaccine-associated enhanced respiratory (VAERD) disease refers to disease with predominant involvement of the lower respiratory tract. Classic examples of VAED are atypical measles and
- enhanced respiratory syncytial virus (RSV) occurring after administration of inactivated vaccine for these pathogens. In this situation, severe disease has been documented resulting from infection in individuals primed with non-protective immune responses against the respective wild-type viruses [2], [3], [4], [5], [6]. Given that these enhanced responses are triggered by failed attempts to control the infecting virus,
- Disease enhancement independent of vaccine priming has also been described for pathogens causing sequential infections with different cross-reactive but not cross-protective serotypes, including dengue and pandemic influenza [7], [8], [9], [10], [11], [12].