Over 110 years have passed since first description of Alzheimer's disease (AD). Despite intensive research, AD remains incurable.
The vast majority of clinical trials on new therapies aimed at suppressing undesirable aggregation of β-amyloid have failed. This requires rethinking of the strategy to fight AD. A lot of evidence supports the maintenance of β-amyloid as the central object of AD pathology, however, its aggregation into larger supramolecular structures is probably an intermediate stage and not the cause of the disease. In the early stages of life, cellular stresses lead to epigenetic changes resulting in later amyloidogenesis and subsequent neurodegeneration. This process takes decades of life trajectory. Therefore, possible therapies should take into account this fact and be applied early in the life and prolonged later. Diagnosis of epigenetic changes leading to AD should be a research priority. If this concept is true, it may give hope to reverse these changes. [Alzheimer's disease - history of failures - a short opinion on the contemporary status of research].Stępkowski D., Postepy Biochem. 2019 Nov 21;65(4):322-324.
The world is in a panic over predictions that Alzheimer's will be a demographic apocalypse by 2050 with more than a hundred and thirty-five million people projected to have dementia.
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Monster In The Mind (Alzheimer's Documentary) - Real Stories
https://www.youtube.com/watch?v=yqdM5UzpvMQ Shocked to discover she is at high risk of Alzheimer’s, 83-year-old CNN veteran Jean Carper, (also the New York Times bestselling author of Stop Aging Now!, Food Your Miracle Medicine and Your Miracle Brain) embarks on a journey to face her fears and find out everything she can to avoid the disease. Investigating Alzheimer’s place in the collective conscience, Carper laments that while working as a journalist earlier in her career, she had made a very different type of Alzheimer’s documentary and became “part of the propaganda machinery to sell Alzheimer’s to the public.” Now, 30-years-later, Carper explores the astonishing story of a disease shrouded in mystery and branded by health care professionals with an outsized and undeserved sense of doom. Weaving together imagery from old horror films with her own experiences of high tech testing led by contemporary research leaders in the field, Carper boldly and at times humorously illustrates a societal fear reminiscent of the world’s most sensational science fiction, horror, and disaster movies. What arises is a surprisingly uplifting vision that can help us save ourselves and the world from dementia. |
HIGHLIGHTS:
NO CURE
Tens of billions of dollars if not more maybe a hundred billion dollars have been spent on trying to cure Alzheimer's. It is increasingly clear that's not working. There is no drug that effectively works to stop the progress of this disease. How can you cure something if you don't even know what causes it. We still don't know what it is or where it comes from.
For about 25 years we've tested Alzheimer's drugs using the theory that it is caused by a brain protein called amyloid beta the sticky protein clumps, called plaques |
Amyloid Hypothesis
John Hardy, a prime author of
'The Amyloid Hypothesis' came out in the early 90s inciting a flood of anti-amyloid drugs to treat old age Alzheimer's. The recent failure rate was 99.6 %. The man who drummed up millions at NIH to study Amyloid now says "clearly amyloid is part of the story but it's not the whole story". This has created this scientific orthodoxy but the true believers in the amyloid hypothesis still dominate Alzheimer's research and they've already begun the boldest experiment ever they're giving anti-amyloid drugs no longer to cure Alzheimer's but to prevent it. It's all based on a radical new concept called Preclinical Alzheimer's, it means that brain plaque builds up for decades before causing any symptoms of dementia |
The A4 Study
About a third of individuals over the age of 65 have a head full of amyloid. The amyloid starts 10 or 20 years before you get dementia.
Dr. Sperling is conducting the first large-scale drug experiment to try to prevent old age Alzheimer's. but Removing Amyloid from normal people may actually cause them become demented sooner or cause further abnormalities. Eli Lilly's newly FDA-approved PET scans is really a big deal because for years the only way that you could ever find out if a person had Alzheimer's plaque in their brain was to do an autopsy. |
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The ROOT CAUSES Of Alzheimer's Disease & How To PREVENT IT
Dr. Dale Bredesen https://www.youtube.com/watch?v=s4EZihtPm_4 In this video, Dr. Dale Bredesen shares inspiring stories from patients who have reversed cognitive decline and are now thriving. He also discusses the contributing factors that lead to cognitive decline and much more. |
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Unconventional But Effective Therapy for Alzheimer's Treatment:
Dr. Mary T. Newport at TEDxUSF Mar 22, 2013 www.youtube.com/watch?v=Dvh3JhsrQ0w 03:13 2005 reported that when they looked at the brains of people who had died with Alzheimer's that did not have type 1 or type 2 diabetes that they found insulin resistance and insulin deficiency in all of these brains and they coined the term type 3 diabetes to indicate Alzheimer's disease they further reported in 2008 that this happened in the earliest.... |
Dementia researchers talk about more than genes and plaques and tangles and drug cures here they're excited about how lifestyle and environment affect your chances of dementia.
TEST FOR A/D
Neurological status (hop on 1 foot 5 times) Short-term memory test EEG test Cardiac fitness test People develop memory loss with aging because their memory part of the brain called hippocampus shrinks by about one percent every two years after it's 50 that's why they have memory loss. The good news - you can absolutely reduce the shrinkage in hippocampus with your lifestyle choices. |
Things that shrink your hippocampus are obesity, diabetes, hypertension, insomnia, sleep apnea, stress, concussions and the more of these you have the more your brain will shrivel away. To stimulate neurogenesis and get more brain cells, the things that make your
brain bigger are exercise, stress reduction, meditation (Na, Ta, Sa, Ma), and a Mediterranean diet. Vigorous walking, swimming, any of these kinds of exercise should be adequate to increase blood flow and increase the proliferation cells every day. Constantly expose your brain to something new like traveling to new countries, learning a new language, learning a new video game, you can indeed turn the clock back when it comes to brain aging. |
Fred "Rusty" Gage found that you're not stuck with a number of brain cells you're born with, you constantly give birth to new stem cells in your hippocampus. If nourished, they survive and grow into fully functioning neurons enlarging your brain capacity. This lifelong process is called neurogenesis. There's somewhere between seven hundred and a thousand new cells being created every day. Activity and enrichment increases the birth of new neurons. |
The history of Alzheimer's
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The Alzheimer's story begins in Germany at the turn of the 20th century in this magnificent
mental asylum called 'The Castle of the Insane' this is where a young Psychiatrist, Alois Alzheimer met a 51 year old demented patient, the doctor's colleagues named her affliction Alzheimer's disease, it was extremely rare; never mentioned in his obituaries and its importance seemed destined to be buried with him. |
Then about 60 years later Alzheimer's disease was resurrected it happened at the National Institutes of Health in the late 1970s Zaven Khachaturian came to NIH to become chief architect of a plan to put Alzheimer's disease on the map. The entity of the phenomena of dementia was known since the ancient Greeks, and Shakespeare wrote about it, but the scientific medical community did not consider it a disease, it considered it as part of the natural consequence of Aging.
Alzheimer's disease is actually a hodgepodge of different diseases. The most common dementia at any age is mixed dementia and how much of it is Alzheimer's - 40% Alzheimer's. 30% cerebral vascular 20% hippocampal sclerosis is 10% DLB dementia with Lewy bodies.
Alzheimer's pathology doubled your likelihood of having dementia but everything else was 4 to 17 times the likelihood choose between one of those if we had a cure for Alzheimer's tomorrow how much difference would it make to be treating that forty percent of people, we'd still be left with 60% of our dementia epidemic. |
The idea of running to get genetic tests to predict whether you're going to get a disease or not is like getting a form of divination; I think that this is what we're playing with here, we cannot with any certainty predict who among us is likely to get Alzheimer's. As many as 50% of those people who have 'positive genetic testing' will never get Alzheimer's, it depends on all sorts of things like your lifelong diet and lifestyle but it also depends on other things that we don't understand we simply don't know enough to be able to predict different types of Alzheimer's.
Most people are not aware that there are two forms - young and old age. Young or early onset Alzheimer's is nearly always determined by genes, usually it's 40s or going into the 50s. Old age Alzheimer's is not the same disease as Alzheimer's at age 65, 70, 80, or 90, and it's very rare. Yes it is rare, the estimates vary but it's something like between and 5% of people who become labeled as Alzheimer's have the early onset. Rita Hayworth was the first poster child for old-age Alzheimer's even though she was stricken in her mid 50s. |
Even having identical genes is not enough to predict old age Alzheimer's. We did a study of identical twins, two men who together went to college to become Chemical Engineers, died in their late 70s within a few years of each other; and one of the twins had florid Alzheimer's disease the other twin had the brain that looked like the brain of a 40 year old. The twin that had Alzheimer's disease had spent his career up to his elbows in DDT. We suspect very strongly that the exposure to DDT altered the epigenetics of the one twins so that he got Alzheimer's disease epigenetics. It means every thing you do, everything that happens to you, switches your genes on and off affecting whether you get Alzheimer's, Dementia and other diseases. So clearly the genes you're born with are not your destiny. |
DDT link to Alzheimer's, Sophie Morlin-Yron, 29th January 2014
https://theecologist.org/2014/jan/29/ddt-link-alzheimers Other hypotheses for Alzheimer's: https://en.wikipedia.org/wiki/Alzheimer%27s_disease |
What's Good for the Brain
Kristine Yaffe
https://www.youtube.com/watch?v=UQYSzwDw9aw B12 - Omeg 3 - studies show that people with high omega-3 (salmon) tend to have a bigger hippocampus Blueberries - Those who consume blueberry tend to have a bigger hippocampus Olive oil - A little red wine - No red meat - One receptor for Aβ oligomers may be the prion protein, the same protein that has been linked to mad cow disease and the related human condition, Creutzfeldt–Jakob disease, thus potentially linking the underlying mechanism of these neurodegenerative disorders with that of Alzheimer's disease. |
Antialzheimeran: https://phytochem.nal.usda.gov/phytochem/activities/show/106?et=
All plant base sources should be ORGANIC otherwise your just soaking up DDT or some other chemical that promotes brain degeneration.
Recent Pat CNS Drug Discov.
2006 Jan;1(1):105-11. Galanthamine, a natural product for the treatment of Alzheimer's disease. Marco L1, do Carmo Carreiras M. Abstract (-)-Galanthamine is a selective, reversible competitive acetylcholinesterase inhibitor that has been recently approved for the symptomatic treatment of Alzheimer's disease. Galanthamine is a natural product belonging to the Amaryllidaceae family of alkaloids. The pharmacological history of galanthamine shows that the bioactive compound was discovered accidentally in the early 1950s, and the plant extracts were initially used to treat nerve pain and poliomyelitis. In addition, galanthamine had since been tested for use in anesthesiology, from facial nerve paralysis to schizophrenia. Galanthamine is a long-acting, selective, reversible and competitive AChE inhibitor that has recently been tested in AD patients and found to be readily absorbed, to be a performance enhancer on memory tests in some patients, and to be well tolerated, although some cholinergic side effects were observed. A number of total synthetic approaches have been reported, and a method for the industrial scale-up preparation of galanthamine is now being developed and patented. A variety of galanthamine derivatives have also been synthesized aiming to develop an agent free from cholinergic adverse effects. Galanthamine is a natural product that complements other synthetic drugs for the management of AD. In this account we will review the recent patent literature showing the most important advance on the chemistry of galanthamine. PMID: 18221196 https://www.ncbi.nlm.nih.gov/pubmed/18221196 Note: During the war when rations were depleting, tulip bulbs and beets were a source of nutrients for locals |
Galantamine
Medicinal Description Galantamine is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. Wikipedia Formula: C17H21NO3 IUPAC ID: (4aS,6R,8aS)- 5,6,9,10,11,12- hexahydro- 3-methoxy- 11-methyl- 4aH- [1]benzofuro[3a,3,2-ef] [2] benzazepin- 6-ol Molar mass: 287.354 g/mol Elimination half-life: 7 hours Metabolism: Hepatic partially CYP450:CYP2D6/3A4 substrate ATC code: N06DA04 (WHO) People also search for: Rivastigmine, Donepezil, Memantine, MORE |
Sound vibration treatment may boost brain activity in Alzheimer’s patients https://www.theglobeandmail.com/life/health-and-fitness/health/sound-vibration-treatment-may-boost-brain-activity-in-alzheimers-patients/article29771676/
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Study of Alzheimer’s Patients Finds Low Frequency Sound Stimulation Improves Cognition https://alzheimersnewstoday.com/2016/04/22/study-alzheimers-patients-finds-low-frequency-sound-stimulation-improves-cognition/
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5 Non-medical, Natural Alzheimer’s Treatments that Work | AssistedLiving.org
There is a clear link between obesity, diabetes, and Alzheimer’s disease. Sugar is known to cross the blood-brain barrier, which has some serious implications on the health of the brain, causing the decay of the synaptic pathways that help us think. Because of this and other symptoms, such as the tendency for those with diabetes to also be obese, diabetes has been shown to be a risk factor for developing Alzheimer’s disease. Guide to healthy eating Healthy Meal Planning: Tips for Older Adults | National Institute on Aging (nih.gov) USDA Food PatternsEating habits can change as we grow older. The USDA has developed Food Patterns to help people understand different ways they can eat healthy. The food patterns include:
Visit the USDA Food Patterns webpage for more information on each eating pattern and recommended daily intake amounts for each food group. |