Receptor type protein tyrosine phosphatases (RPTPs) – roles in signal transduction and human disease
https://www.ncbi.nlm.nih.gov
Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory mechanism contributes to a variety of human diseases including cancer, diabetes, and auto-immune diseases. J Cell Commun Signal. 2012 Aug; 6(3): 125–138.
https://www.ncbi.nlm.nih.gov
Protein tyrosine phosphorylation is a fundamental regulatory mechanism controlling cell proliferation, differentiation, communication, and adhesion. Disruption of this key regulatory mechanism contributes to a variety of human diseases including cancer, diabetes, and auto-immune diseases. J Cell Commun Signal. 2012 Aug; 6(3): 125–138.
Immunodeficiency Syndromes
- In patients with psoriasis or rheumatoid arthritis who have overt or laboratory evidence of immunodeficiency syndromes.
- In patients with psoriasis or rheumatoid arthritis who have pre-existing blood dyscrasias, such as bone marrow hypoplasia, leucopenia, thrombocytopenia or significant anemia.
- In patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease.
Two types of Immunodeficiency Syndromes. Both can be: humoral, cellular or combined
Primary- genetic defects
Primary or Congenital Humoral Immunodeficiencies
1. Hypogammaglobulinemias
2. Bruton's Agammaglobulinemia (X-linked, Primary, baby boys )
2. Hyper-IgM Syndrome (X-linked, Primary)
3. Selective Immunoglobulin Isotype Deficiency (Primary)
4. Common Variable Immunodeficiency (CVID)
5. Cellular Immunodeficiencies
6. Combined Immunodeficiencies
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Acquired (secondary)
Secondary immunodeficiency disorders happen when an outside source like a toxic chemical or infection attacks your body. The following can cause a secondary immunodeficiency disorder:
3. Radiation therapy or radiotherapy
Methotrexate given concomitantly with radiotherapy may increase the risk of soft tissue necrosis and osteonecrosis.(1) 4. Diabetes 5. Malnutrition NO DRUGS FOR (Latex allergy, Active bacterial infection, Latent tuberculosis, Acute hepatits B) Infection, immunosuppressive drugs or malnutrition Acquired immunodefency:
1.Immunosuppressive Drugs Used in Transplantation
1. HIV
Live vaccines
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Parvovirus B19
Parvovirus-associated arthritis
T L Moore. Curr Opin Rheumatol. 2000 Jul;12(4):289-94. https://pubmed.ncbi.nlm.nih.gov/10910181/
Recent studies have shown that parvovirus B19 can cause acute arthritis and occasionally a chronic arthropathy, both in children and adults. Parvovirus B19 DNA has been detected in studies in the synovial tissue of patients with rheumatoid arthritis, but other studies have varied in their findings.
T L Moore. Curr Opin Rheumatol. 2000 Jul;12(4):289-94. https://pubmed.ncbi.nlm.nih.gov/10910181/
Recent studies have shown that parvovirus B19 can cause acute arthritis and occasionally a chronic arthropathy, both in children and adults. Parvovirus B19 DNA has been detected in studies in the synovial tissue of patients with rheumatoid arthritis, but other studies have varied in their findings.